Of note, the median fold change in CD45+EVs was significantly reduced (fold change = 0.59 95% CI 0.36–1.07) in patients achieving disease control, as compared with a 2.88 (95% CI 1.36–4.08) fold change observed in patients with progressive PC (p = 0.005) (Figure 3C,D). The gene discussed is PTPRC; the disease is pachyonychia congenita.