Furthermore, on univariate survival analysis, high blood concentrations at baseline of total EVs, leukocyte-derived EVs (CD45+), PD-L1+ EVs, PD-L1+CD45+, and PD-L1+CD45- were significantly associated with prolonged survival in a cohort of patients with borderline resectable or primary unresectable PC. The gene discussed is CD274; the disease is pachyonychia congenita.