In 2018, Huang et al. [30] developed an MRI-PM including age, serum PSA, DRE, PV measured from TRUS, and mpMRI reported by PI-RADS v2 in 231 suspected PCa men after an initial negative prostate biopsy performed between 2007 and 2017, in whom 2-core guided biopsies to suspicious lesions and/or 12-core systematic biopsies were carried out by transrectal approach in Beijing, China. This evidence concerns the gene KLK3 and posterior cortical atrophy.