BECN1 and colorectal carcinoma: Here, we showed that the protein expression of Beclin 1 negatively correlates with OS and RFS of CRC patients, while there is no significant correlation between the BECN1 mRNA expression and the OS and RFS of CRC patients, which suggests that Beclin 1 protein abundancy is likely influenced by post-translational modifications such as ubiquitylation/deubiquitylation in CRC progression [32].