Given that the present study showed the same tendency as our previous one, we decided to combine both studies, and this allowed us to achieve 2693 BC cases, harboring 10 (likely) LoF (Table 2 and Table 4) and reaching an OR of 2.56 (p = 0.007; 95% CI, 1.21 to 5.15), which, in clear contrast to the rest of helicases, reinforces the position of RECQL5 as a candidate moderate-susceptibility gene in BC. Here, RECQL5 is linked to breast cancer.