Furthermore, our data elaborated that MDM2 ectopic expression neutralized the inhibitory effect of SNHG1 silencing on cell proliferation in vitro and tumor growth in vivo and the promoting effect of SNHG1 silencing on cell apoptosis in vitro in bladder cancer, suggesting the oncogenic role of MDM2 in bladder cancer. This evidence concerns the gene SNHG1 and urinary bladder cancer.