On the one hand, it normalizes the tumor vascular microenvironment by the re-expression of adhesion proteins (mainly claudin-14 and VCAM-1) in endothelial cells, and on the other hand, it also attenuates the inhibition of T cell invasion that is induced by the PAK4/β-Catenin signaling pathway in cancer cells [53,55]. The gene discussed is PAK4; the disease is cancer.