Overexpression and/or overactivation of PAK1 and PAK4 in pancreatic ductal adenocarcinoma (PDAC) promotes tumor growth and metastasis [136]; aMUC13 coordinates the expression and phosphorylation of PAK1 in pancreatic cancer cells, which contribute to pancreatic tumor growth and the prospects of the individual’s survival [137]. This evidence concerns the gene PAK1 and familial pancreatic carcinoma.