PAK4/LIMK1 signaling mediates the chemoprotective action of CXCL12/CXCR4, and the inhibition of PAK4 leads to re-sensitization of pancreatic cancer cells to DTX-induced cellular toxicity even in the presence of CXCL12 [196]. This evidence concerns the gene CXCL12 and familial pancreatic carcinoma.