CCND1 and cancer: Although an aberrant Wnt/β-catenin signal is important in HBL and has a role in cancer stemness [12,39,40,41], expression of the downstream target genes MYC and CCND1 did not change with modified ADAM32 expression, suggesting that regulation of stemness by ADAM32 might be independent of the Wnt/β-catenin signaling pathway.