According to Bolanz et al. (2008), 17-β estradiol upregulates, in a time-dependent manner, TRPV6 expression in T-47D breast cancer, suggesting that TRPV6 channels facilitate the calcium influx and are part of the molecular mechanism of the 17-β estradiol-induced proliferation in breast cancer cells. This evidence concerns the gene TRPV6 and breast carcinoma.