A comparative analysis further suggested that the gene expression of SRSF2, SRSF6, SRSF9, SRSF11 and SRSF12 with CNV gain in tumors was significantly higher than that in the HCC without CNV gain samples (Figure 1G), which partially explained the abnormally elevated expression of these genes in HCC. This evidence concerns the gene SRSF12 and hepatocellular carcinoma.