AKT1 and hepatocellular carcinoma: We first performed a GSVA, which consistently revealed that cell division-related pathways, PI3K/AKT/mTOR signaling pathways and P53 signaling pathways were highly activated in HCC patients with high SRSF scores, while metabolism and immune-related pathways were highly activated in HCC patients with low SRSF scores (Figure 6A).