FGFR1 and neoplasm: They claimed that RAPGEF5 suppression could attenuate the transmembrane signaling receptor “fibroblast growth factor receptor 1 (FGFR1)” and thus suppress tumor growth by binding to miR-198, which sponged the 3′-UTR of FGFR1 via circRAPGEF5 targets in vitro.