CiRS-7/miR-7/EGFR [78], circ_0067934/PI3K/AKT [121], circ_0067934/miR-1301-3p/HMGB1 [146], and circ_0062389/miR-1179/HMGB1 [117] regulate the EMT process and thus cancer tissue invasion/metastasis. The gene discussed is HMGB1; the disease is cancer.