In patients with adenomyosis, the expression of several inflammatory cytokines, such as IL-1β, IL-6, IL-8, IL-10, TNF, NF-κB, MCP-1, and RANTES, is abnormal, and a variety of signaling pathways such as TLR437 and MAPK/ERK are involved. This evidence concerns the gene NFKB1 and adenomyosis.