FLT3 and acute myeloid leukemia: Indeed, for patients harbouring the FLT3-ITD mutation, as the pivotal AML mutation, the recently approved, highly selective, second-generation FLT3 inhibitors may represent the optimal bridge to transplant, as recently demonstrated in the QuANTUM-First trial with the addition of quizartinib to a 3+7 induction treatment [36].