In this monocentric, real-life study, AML patients carrying the two most frequent mutations, FLT3 and or NPM1, homogeneously treated over a period of 17 years with an aggressive idarubicin-based induction and the integration of idarubicin in the HD-ARAC consolidation, achieved an outstanding CR rate of 88.3% after one course of induction (ICE) and overall survival at 5 years of 58%. This evidence concerns the gene FLT3 and acute myeloid leukemia.