ICD is characterized by the coordinated release of a series of damage-associated molecular patterns (DAMPs), including the exposure of calreticulin (CRT) on the surface of dying cancer cells, the secretion of adenosine triphosphate (ATP), the release of high mobility group box 1 (HMGB1) and the activation of type I interferon (IFN) response [8,9,10]. The gene discussed is HMGB1; the disease is cancer.