KLK3 and metastatic neoplasm: We included seven known prognostic factors (circulating tumor cell (CTC) > 4, Lactate Dehydrogenase (LDH) > 230 IU/L, Alkaline phosphatase (ALP) > 147 IU/L, Prostate-specific antigen (PSA) > 4 ng/mL, high metastatic disease volume, Gleason score > 7, and Age > median age of the cohort) and performed Cox regression at the univariate level in both cohorts (Figure 4a,b).