These observations indicated that Fasudil induced apoptosis in EGFR-mutation NSCLC cell lines in a dose-dependent manner, and 75 μM Fasudil has a stronger apoptosis-promoting effect on gefitinib-resistant H1975 cells than gefitinib-sensitive cells (HCC827 and PC9). This evidence concerns the gene EGFR and non-small cell lung carcinoma.