AKT1 and cancer: The EGFR pathway regulates various cellular functions, including cancer cell proliferation, survival, metastasis, and angiogenesis, through the activation of its multiple downstream pathways, such as RAS/RAF-MEK (mitogen-activated protein kinase)-ERK1/2 (extracellular signal-regulated kinase), PI3K (phosphatidylinositol-4, 5-bisphosphate 3-kinase)/AKT (a serine/threonine protein kinase), and JAK2- STAT3/5 (signal transducer and activator of transcription) [4,5].