The analysis of the serum levels of the circulating ligands of TNF-alpha-induced apoptosis revealed significant differences between the CIN I-II dysplastic group and both the healthy donors and the low oncogenic HPV-infected groups for sFAS, IL-2, and TRAIL (p < 0.05), and even more marked (p < 0.01) in the case of TNF-alpha. This evidence concerns the gene TNFSF10 and cervical squamous intraepithelial neoplasia.