The anti-proliferative effect of the dietary anti-carcinogenic compound phenyl ethyl isothiocyanate in human cancer stem cells, derived from the human cervical tumour-derived HeLa cell line, partially resulted from the up-regulation of death receptors DR4 and DR5 of the TRAIL-mediated apoptotic pathway [86]. The gene discussed is TNFSF10; the disease is uterine cervix neoplasm.