MUC16 and cholangiocarcinoma: Multivariate Cox regression analysis revealed that MUC16 (+) (HR = 1.6, 95% CI = 1–2.6, p = 0.032), ECOG 1 (HR = 2, 95% CI = 1.3–3.2, p = 0.003), multiple tumors (HR = 1.7, 95% CI = 1.1–2.7, p = 0.025), as well as the presence of tumor marker CA-19/9 (HR = 1.6, 95% CI = 1–2.6, p = 0.035) serve as independent risk factors for overall survival for CCA patients in our study (Table 2).