The analysis of the same 12 genes in the K562 cell line highlighted the deregulation of 6/12 genes, but only two (PRMT5, PRPF8) were in common with primary immature CP-CML cells, underlying their potential role already in the early CP-CML phase. Here, PRPF8 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.