We found that while the wild-type Keap1 transgene (Tg-Keap1WT) is able to rescue esophageal hyperkeratosis in Keap1–/– mice [91], Keap1 point mutant transgenes (Tg-Keap1 mutant), including C273&288A, G364C and G430C, cannot rescue hyperkeratosis and lethality. This evidence concerns the gene KEAP1 and Hyperkeratosis.