In addition, IL-2, IL-12, and Tumor Necrosis Factor Alpha (TNF-a), all well-studied immunostimulatory transgenes, are also associated with immunosuppression (and, interestingly, intralesional mRNA injections of these factors have not performed so well); (3) presence of the coxsackievirus and adenovirus receptor (CAR), which mediates viral attachment and infection [18,19,20]. This evidence concerns the gene TNF and infection.