Rather, AdAPT-001 is detargeted from non-tumor cells through the deletion of a small 50 base pair region located upstream of the E1A initiation site, which contains multiple transcription factor binding sites that are indispensable in non-tumor cells, leading to abortive infection and no or restricted cytolytic activity, but dispensable in tumors, where potent near wild type levels of replication, expression, and cytolytic activity are observed [22,23,24]. The gene discussed is DHTKD1; the disease is neoplasm.