Despite the similarity, their expression profiles seem different: PD-L1 is predominantly expressed on tumor cells and on tumor infiltrating immune cells (in particular CD3+ and CD8+), but also in normal human tissue such as myeloid dendritic cells (DCs), macrophages, placental trophoblasts, myocardial endothelium and cortical thymic epithelial cells [28]. The gene discussed is CD274; the disease is neoplasm.