FOXA1 and neoplasm: In particular, it has been demonstrated that the role of FOXA1 in different cancer locations may vary, e.g., from the tumor suppressor (for instance, in hepatocellular carcinomas by suppressing PIK3R1 expression [16]) or tumor promoter (for example, in breast and prostate cancer by binding to ERE and ARE motifs [17,18]), highlighting the complexity of its functions.