FOXA1 and breast cancer: In particular, FOXA1 is able to: (1) mediate the uptake of extracellular lipid precursors to increase tumor proliferation [29,31]; (2) modulate ER activity by binding to the ESR 1 promoter and favor both ER mRNA and protein expression in BC cells [24,30]; and (3) drive cell-cycle progression through the stimulation of cyclin D1 [32], cyclin E2, and E2F1 genes [18,33] (Figure 1b–d).