In the other group, metallothionein-1G (MT1G) has a high content of cysteine residues that bind various heavy metals and, as a transcriptional target of NRF2, could ameliorate heavy metals and free radicals to maintain cellular redox homeostasis while it is upregulated in sorafenib-resistant hepatocellular carcinoma cells [41]. This evidence concerns the gene MT1G and hepatocellular carcinoma.