Mutations occurring in the non-NF2 (neurofibromatosis type 2 gene, [45])-mutated meningioma include TRAF7 (Tumor Necrosis Factor Receptor Associated Factor 7, [45]), AKT (protein kinase B), SMO (smoothened frizzled class receptor, [45]), and PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, [45]) genes, which are strongly related to the meningioma subtypes and are typically associated with low-grade (CNS WHO grade 1) meningiomas [45]. This evidence concerns the gene PIK3CA and meningioma.