RUNX1 and acute myeloid leukemia: For instance, the 11p15.5 breakpoint region in children with AML contains RDPX1 pseudogene [47] and translocations t(8;21) and t(3;21) span the region of the RUNX1 gene locus with pseudogenes RPL34P3, EZH2P1, RPS20P1, MTND2P1 and MTCO1P1 [48].