The function of GBF1, HTT and SPG11 in the pathophysiology of AML and CML is unknown, although a study of huntingtin interacting protein 1 (HIP1) expression in AML patients suggests that HTT may be associated with overall survival of AML patients via HIP1 [84]. Here, HTT is linked to chronic myelogenous leukemia, BCR-ABL1 positive.