ART4 and chronic myelogenous leukemia, BCR-ABL1 positive: Gene ontology (GO) annotations further suggested a role of U2-dependent pre-RNA splicing, RNA, reactive oxygen species and glycoprotein metabolism, the cellular endomembrane system, secretory granules, neutrophil migration, antimicrobial humoral immune response and antifungal defense system in the pathophysiology of AML and CML.