In the present study, we showed that AML and CML differ in glycosylation catalyzed by ALG8 alpha-1,3-glucosyltransferase (ALG8), carbohydrate sulfotransferase 14 (CHST14), exostosin glycosyltransferase 2 (EXT2), protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) (POMGNT1), protein O-mannosyltransferase 2 (POMT2) and transmembrane protein 258 (TMEM258) and 59 (TMEM59). The gene discussed is TMEM59; the disease is acute myeloid leukemia.