Whether the differences in mRNA expression of genes associated with extracellular vesicles (GBF1, HTT, SPG11) and secretory granules (CRISP3, CAMP, LTF, OLFM4, DC177) between AML and CML reflect differences in the pathogenesis of AML and CML or are simply the result of different myeloid lineages affected by a disease is unknown and is yet to be determined. The gene discussed is GBF1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.