Compared with normal tissues, IGF2BP2, HNRNPC, YTHDF1, HNRNPA2B1, KIAA1429, RBM15, ELAVL1, FMR1, METTL3, IGF2BP3, HNRNPG, WTAP, IGF2BP1, METTL16, YTHDF2, CBLL1, ALKBH5, YTHDF3, METTL14, FTO, YTHDC1 were highly expressed in HNSCC tissues. The gene discussed is YTHDF2; the disease is head and neck squamous cell carcinoma.