In in vivo experiments, knockdown of JWA promotes lung metastasis of melanoma in a tail vein injection model of B16F10 melanoma cells; in addition, knockdown of JWA promotes lymph node metastasis of melanoma cells in a tail vein injection lung metastasis model of human-derived melanoma cells (A375 cells) (lymph node metastasis occurred in 40% of mice in the knockdown JWA group; and none in the control group) [16]. The gene discussed is ARL6IP5; the disease is melanoma.