However, mutations in several other genes such as melanocortin 1 receptor (MC1R), microphthalmia-associated transcription factor (MITF), cyclin-dependent kinase 4 (CDK4), protection of telomeres 1 (POT1), telomerase reverse transcriptase (TERT), adrenocortical dysplasia (ACD), telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP) and BRCA1-Associated Protein 1 (BAP1) are also present in melanoma-prone families [72,73]. The gene discussed is CDK4; the disease is granular corneal dystrophy type II.