GLP1R and type 2 diabetes mellitus: Moreover, the beneficial role of GLP-1 RAs on patients with T2D and NASH was demonstrated in a meta-analysis by Zhu et al., concluding that GLP-1 RAs greatly reduced intrahepatic adipose tissue, weight mean difference, subcutaneous adipose tissue and visceral adipose tissue, while the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), body weight, body mass index, waist circumference, fasting blood glucose, hemoglobin A1c (HbA1c), total cholesterol and triglycerides were significantly decreased [43].