TNF and metabolic dysfunction-associated steatohepatitis: Finally, in a diet-induced mouse model of NASH, exenatide had a beneficial effect on the lipid metabolism and attenuated the hepatic lipid byproducts that were correlated with insulin resistance and lipotoxicity, while at the same time decreased the expression of hepatic lipogenic genes (Srebp1C, Cd36) and genes associated with liver inflammation and fibrosis (Tnfa, Timp1) [36].