Results revealed that 20 patients of 138 cases with DLBCL (14.5%), corresponding to 20.4% of the 98 GC-DLBCL, had EZH2 mutations, as follows: Y641F (n = 7, 5.1%), Y641N (n = 4, 2.9%), Y641H (n = 3, 2.2%), Y641S (n = 3, 2.2%), I638T (n = 1, 0.7%). The gene discussed is EZH2; the disease is diffuse large B-cell lymphoma.