Kim et al. analyzed cancer stem cells genes in histological samples derived from tumor biopsies (EpCAM, CK8, SALL4, ALDH1A1, CD13, CD24, CD44, CD90, CD133, ALB, AFP) as prognostic biomarkers in 47 patients with advanced HCC treated with sorafenib. This evidence concerns the gene PROM1 and hepatocellular carcinoma.