There are several parameters that can be considered valuable prognostic parameters for HCC: serum proteins such as AFP and its glycosylated form (Lens culinaris agglutinin-reactive AFP or AFP-L3), des-γ-carboxy prothrombin (DCP, or prothrombin induced by vitamin K absence II [PIVKA II]), tumor number and dimension, status of surgical margins, neoplastic stage, vascular invasion, portal hypertension, and Child-Pugh score [10]. The gene discussed is AFP; the disease is portal hypertension.