When VLS-101 binds to ROR1 on DLBCL-type RS cells, the complex is internalized by the cell and included in lysosomes, where, via proteolytic cleavage, MMAE is released and can fulfill its cytotoxic function, blocking cell cycle progression and inducing apoptosis in the neoplastic cell (Figure 2) [114]. Here, ROR1 is linked to diffuse large B-cell lymphoma.