Mutational analysis performed by CAPP-Seq with an ample panel of genes affected in B-cell neoplasia revealed that genetic lesions of clonally unrelated DLBCL-type RS predominantly involve tumor suppressor genes implicated in the DNA damage response (TP53, ATM) as well as genes regulating cell cycle and proliferation (NOTCH1, ID3, and MYC) [72]. The gene discussed is NOTCH1; the disease is diffuse large B-cell lymphoma.