The discussed mechanisms involved loss of let-7-regulated suppression and subsequent upregulation of genes, such as E-cadherin transcriptional repressors ZEB1 and SIP1 in a breast cancer model, GAB2 and FN1 in mammary carcinoma, and developmental genes Twist and Snail in an oral squamous cell carcinoma (OSCC) model. This evidence concerns the gene SNAI1 and breast carcinoma.