CTLA4 and hepatocellular carcinoma: In a study by Macek Jilkova et al., the composition and expression of CD in blood lymphocytes, natural killer (NK) T cells, and NK cells were evaluated and compared to T cells and NK cells within the liver in 21 patients with advanced HCC treated with Sorafenib [44]; the CD31+ and CD56+ T-cells found in the blood accounted for more than 60% of all CD45-high lymphocytes, whereas in the liver, their frequency decreased to 50%.