TP53 and hepatocellular carcinoma: A qualitative analysis of somatic gene mutations in HCC-derived ctDNA fragments showed that several oncogenes and tumor suppressor genes such as ARIDNA, tumor protein 53 (TP53), catenin (cadherin-associated protein), and beta 1 (CTNNB1) are involved, and the same mutations were found in tumor tissue in 63% of cases [82,83].