CD274 and hepatocellular carcinoma: However, a recent study including 11 Caucasian cirrhotic patients with HCC treated with Tremelimumab and/or Durvalumab demonstrated that those who achieved DCshowed a lower fecal calprotectin concentration and PD-L1 serum levels at baseline; also, the pre-treatment increased the abundance of Akkermansia observed in patients who achieved DC, in parallel with a reduction in Staphylococcus, Neisseria, and Enterobacteriaceae [197].