As has been well documented by others, a compensatory increase in the ErbB3 expression and ErbB3 phosphorylation occurs in the MK2206-treated PCa cells (Figure 4A,B; lanes 3 and 4), which is consistent with the known inhibitory action of AKT on the ErbB3 transcription factor FOXO. The gene discussed is ERBB3; the disease is posterior cortical atrophy.