Although PTEN loss (such as in PC3 and PC3/Pac cells) leads to an activated state of AKT under basal conditions, and potentially renders the cells as more susceptible to AKT inhibition (Table 1), AKT and ErbB co-targeting leads to synergistic anti-cellular responses in the PCa cells, independent of their constitutional PTEN status (Table 2). Here, EGFR is linked to posterior cortical atrophy.