Certain subtypes of L-RGS2 HGSOC held co-expression of genes coding for elements of tumor-cell integrity and tumor cell plasticity such as KLK8 (p = 1.13 × 10−5), KLK6 (p = 8.07 × 10−3) or SLPI (p = 2.94 × 10−8), CLDN7 (p = 5.16 × 10−5), SMIM22 (p = 1.82 ×10−8) and genes associated with the innate immune system pathway such as VAMP8 (p = 3.59 × 10−9), IFI27 (p = 2.43 × 10−13), and LGALS3 (p = 8.94 × 10−8). The gene discussed is SMIM22; the disease is neoplasm.