PMEL and uveal melanoma: As we previously detected [9], CHCs (gp100+/CD45+, or TYR+/CD45+) were readily identified in all uveal melanoma peripheral blood specimens, while CTCs (gp100+/CD45− or TYR+/CD45−) were found at low levels or absent in all patients, (Figure 1A,B and Supplemental Figure S1A).