PIK3R1 and familial pancreatic carcinoma: miR-206 inhibits lymphangiogenesis in pancreatic cancer [11], and circNFIB1 interacts with miR-486-5p to regulate miR-486-5p/PIK3R1/VEGF-C and inhibit lymphatic proliferation, tube hyperplasia, and metastasis in pancreatic cancer [12].