The general results of leukemia have shown that: (i) SIRT2 and SIRT3 can be considered as important prognostic markers for the disease, (ii) in ALL, SIRT2 participates in processes such as tumor growth and (iii) in CLL, SIRT3 acts in the control of reactive oxygen species [51,66]. This evidence concerns the gene SIRT3 and B-cell chronic lymphocytic leukemia.