High levels of SIRT1 can reduce the level of inflammation caused by lipopolysaccharides in CML k562 cells, reducing toll-like 4 receptor (TLR4) sensors relevant to inflammation, as well as the reduction of NF-kB and p65, causing a decrease in ROS [57]. The gene discussed is TLR4; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.