KDR and adrenocortical insufficiency: Although actual incidence and prevalence cannot be derived from spontaneous reporting, the fact that VEGFR-TKIs were reported in 314 cases over the past few years (3.25% of total adrenal hypofunction reports in FAERS) suggests that the estimated AI risk is not so rare, and we advocate for an update of the relevant summaries of product characteristics where AI is not mentioned.