Cell line dependency has also been reported for the anti-cancer effects of paclitaxel, in which the mechanism of cytotoxicity was revealed to be upregulating death receptor 5, thereby activating the extrinsic pathway of apoptosis in prostate cancer cell lines, but not in NSCLC or breast cancer cell lines [48]. The gene discussed is TNFRSF10B; the disease is Familial prostate cancer.