Specifically, in three screening studies [39,51,86] that tested against melanoma (M-14 and SK-Mel-19), K-RAS-mutant lung cancer (A-549, H-23, and H-1573), and colon cancer (HCT116 and RKO) cell lines, several benzimidazoles showed inhibitory effects, but the levels of these effects differed depending on the benzimidazole type. This evidence concerns the gene KRAS and colonic neoplasm.