When NCZ was treated with an inhibitor of heat shock factor (HSF) 1 or the MEK/extracellular signal-regulated kinases (ERK) pathway, it exerted higher cytotoxicity than NCZ alone, thereby lessening the chemotherapeutic resistance promoted by ERK-1/2-dependent HSF1 in colorectal cancer cells [84]. The gene discussed is MAPK3; the disease is colorectal cancer.