When analyzing breast cancer gene alterations, researchers have discovered that the JAK2 and STAT3 pathway components undergo several nonsense substitutions, splice site mutations, and frameshift indels, resulting in the inactivation of the pathway both in ER+ and triple-negative cancers; even though the primary tumor cells lacked the aforementioned changes, it still led to metastasis [138]. The gene discussed is STAT3; the disease is breast cancer.