In contrast the loss of E-cadherin, and the accompanying replacement by N-cadherin, known as cadherin switch, proves to be an influential force in establishing the mesenchymal phenotype because anchoring and communicative properties of E-cadherin to neighboring cells is lost, giving cells the ability to relocate from the original site and invade other tissues or organs such as in the progression of cancer [57,82]. Here, CDH2 is linked to cancer.