CDH2 and cancer: Additional crossover may occur with STAT3 signaling which is blocked by RKIP, and although more research needs to be done to look at this pathway, it seems that GATA-AS1 could also inhibit STAT3 signaling, meaning RKIP and GATA3-AS1 play a similar role in blocking cancer proliferation through STAT3 signaling and N-cadherin [183] (Figure 3).