E-cadherin plays a role in deactivation of Hippo signaling for cell proliferation through cell–cell contact and sets off a phosphorylation event of the YAP protein in the Hippo pathway that represses proliferation, meaning destabilization of E-cadherin through EpCAM interactions could lead to activation of Hippo signaling and increased cell proliferation such as in the cancer cell phenotype [138]. This evidence concerns the gene EPCAM and cancer.