As PD-L1 is a known marker of tumor progression [64,65], our findings of the colocalization of PDL1 with GDF-15 in PCa but not in BPH is a novel discovery that could be used in future, prospective studies as biomarkers of malignancy in tissue biopsies or cells/RNA in urine or seminal plasma [66,67]. This evidence concerns the gene CD274 and benign prostatic hyperplasia.