BRCA2 and ovarian cancer: Since BRCA1 P/LPV carriers tend to develop ovarian cancer at younger ages than BRCA2 P/LPV carriers [54], most reviewed guidelines addressing this question recommend rrBSO after finalizing family planning between 35 and 40 years of age for BRCA1 P/LPV carriers, and between 40 and 45 years of age for BRCA2 P/LPV carriers (Table 1).