A meta-analysis of 44 studies published in 2014 focusing on hormonal and exogenous risk factors for breast cancer in BRCA P/LPV carriers reported that the only variable displaying a statistically significant association with reduced breast cancer risk is late age at first live birth (>30 years vs. younger and 25–29 years vs. younger) in BRCA1 (but not in BRCA2) P/LPV carriers (Effect Size = 0.65; 95% CI = 0.42 to 0.99) [17]. This evidence concerns the gene BRCA1 and breast cancer.