BRCA1 and biliary tract cancer: A recent large retrospective, family-based study suggested a small, but statistically significant, increased risk for gastric cancer in BRCA P/LPV carriers (RR = 2.17 for BRCA1 and RR = 3.69 for BRCA2), slightly increased risk for biliary tract cancers in BRCA1 P/LPV carriers (RR = 3.34), and for colorectal cancer in BRCA1 P/LPV carriers (RR = 1.48) [7].