Germline pathogenic/likely pathogenic variants (P/LPVs) in the BRCA1 (OMIM 113705) and BRCA2 (OMIM 600185) genes were the first clinically significant genetic risk factors identified in families displaying an unusual cluster of breast and ovarian cancer—Hereditary Breast Ovarian cancer syndrome (HBOC) [1,2]. The gene discussed is BRCA1; the disease is ovarian carcinoma.