The tumor tissue concentration of FGF23 was significantly increased in 100 IU+cal 4T1 tissue; in 67NR tumors, it was increased in the 5000 IU and 100 IU groups as compared to the control 1000 IU group; and it was diminished in the 100 IU+cal as compared to the 100 IU group. Here, FGF23 is linked to neoplasm.