Interestingly, vitamin D deficiency (which in general does not lead to increased metastatic process, like vitamin D3 supplementation or calcitriol administration in the 4T1 model, but shows a tendency for an increased number of micrometastases [3]) also led to decreased NFs activation in the 4T1 model (decreased podoplanin and TNC) and to some signs of increased activation of CAFs in the E0771 model (increased podoplanin). The gene discussed is PDPN; the disease is vitamin D deficiency.