TNC and vitamin D deficiency: Interestingly, vitamin D deficiency (which in general does not lead to increased metastatic process, like vitamin D3 supplementation or calcitriol administration in the 4T1 model, but shows a tendency for an increased number of micrometastases [3]) also led to decreased NFs activation in the 4T1 model (decreased podoplanin and TNC) and to some signs of increased activation of CAFs in the E0771 model (increased podoplanin).