The plasma concentrations of OPN were diminished in the 100 IU vitamin-D3-deficient group in 4T1-bearing mice and in 100 IU+cal in 67NR tumor-bearing mice, but in healthy BALB/c and C57BL6 mice, the concentration was the highest in the 100 IU+cal group (Table 5). This evidence concerns the gene SPP1 and neoplasm.