Furthermore, in a Kras-based transgenic murine model of late-stage PCa (KPC; FoxP3DTR mice), where Tregs can be depleted at will upon the administration of diphteria toxin in the context of spontaneous carcinogenesis, Treg depletion led to a compensatory recruitment of MDSC and other CD4+ T cells. This evidence concerns the gene CD4 and posterior cortical atrophy.