Some studies have found that PFKFB3 plays a key role in the repair of DNA damage by homologous recombination, leading to the development of the small-molecule PFKFB3 inhibitor KAN0438757 (Figure 5F), suggesting that PFKFB3 may play a key role in the initiation and development of malignant tumors [180]. The gene discussed is PFKFB3; the disease is cancer.