PKM and neoplasm: In addition, many molecules, such as parthenolide (PTL 5) (Figure 6I) [233], ML-265 (Figure 6K) [234], PA-12 [235], Pyridin-3 ylmethyl carbamodithioic esters [236], ZINC08383544 [237], and compound 0089-0022 [238], inhibit tumor growth as PKM2 agonists.