TGFB1 and neuroblastoma: Examples include the modification of the chemokine milieu [15], the production of indoleamine 2,3-dioxygenase (IDO) and prostaglandin E2 (PGE2), the release of immunomodulatory cytokines such as TGF-β1 [27], the downregulation of HLA-I, a phenomenon typical in NB, and PVR, the ligand of DNAM-1 activating receptor [28].