Inadequate tumor immunogenicity associated with a low TMB, gene mutation, the lack of antigen presentation and PD-L1 expression, and mutations in the PI3K-Akt, IFN, and Wnt/B-catenin signaling pathways are considered as tumor intrinsic immunoresistance mechanisms, while immunosuppressive TME, epigenetic modifications, and the expression of alternative immunocheckpoints are associated with tumor extrinsic immunoresistance mechanisms [215]. Here, CD274 is linked to neoplasm.