The first generation ALK inhibitor crizotinib, receiving accelerated approval by the FDA in 2011 for metastatic NSCLC, showed a median of 7.7 months PFS versus 3.0 months in chemotherapy controls pemetrexed or docetaxel in a phase III clinic trial A8081007 [185,186]. This evidence concerns the gene ALK and non-small cell lung carcinoma.